Welcome to Kaneka Medical America LLC

Familial Hypercholesterolemia (FH)

Familial Hypercholesterolemia is an inherited disorder that, if untreated, leads to aggressive and premature cardiovascular disease (CVD) resulting in heart attacks and strokes. In FH patients, genetic mutations make the liver incapable of metabolizing excess low-density-lipoprotein cholesterol (LDL cholesterol, “bad cholesterol”). The result is very high LDL cholesterol which can lead to premature CVD.

There are two forms of FH. If you have inherited this genetic mutation from one parent, then you will have Heterozygous FH. If you inherit FH from both parents, this form of FH is called Homozygous FH, a condition that results in even higher levels of LDL cholesterol.

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Focal Segmental Glomerulosclerosis Photo

Focal Segmental Glomerulosclerosis (FSGS)

Primary focal segmental glomerulosclerosis (FSGS) is a disease of the kidney that has no known cause. FSGS is named for the scarring, or “sclerosis” found in the kidneys of patients. Under a microscope, everyone’s kidneys contain millions of tiny filters called “glomeruli”. When these filters are damaged, they become scarred and are no longer able to filter blood appropriately. This is called “glomerulosclerosis”. The word "focal" means only some of the filters are damaged. "Segmental" means only parts of the filters are scarred.

FSGS causes large losses of protein in your urine because your kidneys are not working properly. This loss of protein causes low amounts of protein to be in your blood. Low blood protein prevents your blood vessels from holding onto water. When this occurs, water leaks out under your skin and can cause swelling.

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Dialysis-Related Amyloidosis (DRA)

Dialysis-related amyloidosis (DRA) is a major complication that affects patients with end stage renal disease (ESRD) who have been receiving long-term hemodialysis treatment (typically 5 years or more). Hemodialys is not able to remove all of the substances from the blood due to limitations of the dialyzer filter, leading to accumulation of a protein molecule β2-microglobulin (β2m).

The normal kidney filters and removes excess proteins such as β2m from the blood, keeping blood levels of such proteins normal. When the kidney fails to function properly, β2m builds up in the blood and may form deposits called amyloid fibrils that deposit in various areas of the body and may cause pain, stiffness and lack of mobility. Patients with DRA may have joint pain, back pain, carpal tunnel syndrome and an increase in the rate of bone cysts and fractures.

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Epiphora

Excessive tearing, also known as epiphora, is due to a disruption in the balance between tear production and tear drainage. When the tears don't drain properly, even the slightest stimulus can cause them to overflow, blurring the patient’s vision, and the constant flow of tears can inflame the skin around your eyes. The main cause of poor tear drainage is Lacrimal duct obstruction. This obstruction can result from aging, infection, medicine such as eye drops, fractures of facial bones, empyema, and other nasal diseases.

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2/10/2022 - URGENT: MEDICAL DEVICE RECALL ‹LIPOSORBER© LA-15 SYSTEM Labeling›

Therapy Areas

Familial Hypercholesterolemia (FH)

Focal Segmental Glomerulosclerosis (FSGS)

Dialysis-Related Amyloidosis (DRA)

Epiphora

Mission

To contribute to human well-being through the application of biomedical engineering in the research, design, and sale of devices that promote health.

Location

Kaneka Medical America LLC

History

Kaneka Group

Leveraging Our Science to Make Wishes Come True, All Around the World